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Healthier Heart: Decreased Left Ventricular Mass

Significant improvements in measures of the heart's ventricular structure and function in African American adolescents at risk for essential hypertension

Barnes VA, Treiber FA, Kapuku G. Impact of Transcendental Meditation on left ventricular mass in African American adolescents. Annals Behavioral Medicine. 2009;37(Supplement):S195.

Chronic stress may cause blood pressure to be sustained at too high a level and cause enlargement of the left ventricle, the chambers in the heart responsible for pumping blood to the body. This enlargement of the heart, called left ventricular hypertrophy, is a strong predictor of cardiovascular disease. This study on 49 adolescents found significant decreases in Left Ventricular Mass (LVM, p < .04) over an eight-month period in the TM group compared to the health-education control (CTL) group. This study and the one on weight control are further analyses of a previously published randomized controlled trial (Barnes VA, Johnson MH, Treiber FA. Impact of Transcendental Meditation on ambulatory blood pressure in African American adolescents. American Journal Hypertension. 2004;17(4):366-369.)

Truth LVM Barnes
Abstract

Impact of Transcendental Meditation on left ventricular mass in African American adolescents

Vernon A. Barnes, Frank A. Treiber, Gaston Kapuku, Medical College of Georgia

Background: The recurrent and/or sustained exaggerated increases in blood pressure responses to stress are associated with concomitant increases in cardiac and vascular wall tension.  It is hypothesized that over time this leads to secondary cardiovascular structural adaptation, that is, vascular and ventricular remodeling to help normalize wall tension.  An early sign of ventricular remodeling is increased left ventricular mass (LVM) which over time may lead to left ventricular hypertrophy, the strongest predictor of cardiovascular morbidity and mortality, other than advancing age.

Methods: 49 subjects (27 TM; 22 CTL) African American adolescents (age 16.2±1.3 years) with high normal systolic blood pressure, were randomly assigned to either 4-month TM or health education control groups.  The echocardiographic derived measure of Left Ventricular Mass (LVM), as well as Left Ventricular Mass Index (LVMI = LVM/ht2.7) were measured before and after the 16-week TM study.  2-D guided M mode echocardiography using a Hewlett Packard 5500. M-mode was used to determine interventricular septal thickness, LV cavity dimension and LV free (posterior) wall thickness in triplicate in accordance with the American Society of Echocardiography (ASE) convention. LVM was determined using the following validated formula. LVM = 0.8 [1.04 x ((IVSd + LVEDd + LVPWd)3 - LVEDd3)]+0.6. 

Results: The TM group exhibited a greater decrease in LVM (-3.3 vs.+ 4.6 gm, p<.05), as well as LVMI (-.85 vs +1.1, gm/ht2.7 p<.03), compared to the CTL group. 

Conclusion: These preliminary findings, which require cross validation, indicated significant decreases in LVM and LVMI in the TM group compared to CTL.  These findings indicate significant improvements in measures of ventricular structure and function (i.e., decreased LVMI) in African American adolescents at risk for essential hypertension. 

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